Socs1 Deficiency Enhances Hepatic Insulin Signaling
نویسندگان
چکیده
منابع مشابه
The Epoxyeicosatrienoic Acid Pathway Enhances Hepatic Insulin Signaling and is Repressed in Insulin-Resistant Mouse Liver*
Although it is widely accepted that ectopic lipid accumulation in the liver is associated with hepatic insulin resistance, the underlying molecular mechanisms have not been well characterized.Here we employed time resolved quantitative proteomic profiling of mice fed a high fat diet to determine which pathways were affected during the transition of the liver to an insulin-resistant state. We id...
متن کاملPulsatile Portal Vein Insulin Delivery Enhances Hepatic Insulin Action and Signaling
Insulin is secreted as discrete insulin secretory bursts at ~5-min intervals into the hepatic portal vein, these pulses being attenuated early in the development of type 1 and type 2 diabetes mellitus (T2DM). Intraportal insulin infusions (pulsatile, constant, or reproducing that in T2DM) indicated that the pattern of pulsatile insulin secretion delivered via the portal vein is important for he...
متن کاملSestrin 3 Protein Enhances Hepatic Insulin Sensitivity by Direct Activation of the mTORC2-Akt Signaling
Sestrin proteins have been implicated in multiple biological processes including resistance to oxidative and genotoxic stresses, protection against aging-related pathologies, and promotion of metabolic homeostasis; however, the underlying mechanisms are incompletely understood. Some evidence suggests that sestrins may inhibit mTORC1 (mechanistic target of rapamycin complex 1) through inhibition...
متن کاملMitochondrial complex I deficiency enhances skeletal myogenesis but impairs insulin signaling through SIRT1 inactivation.
To address whether mitochondrial biogenesis is essential for skeletal myogenesis, C2C12 myogenesis was investigated after knockdown of NADH dehydrogenase (ubiquintone) flavoprotein 1 (NDUFV1), which is an oxidative phosphorylation complex I subunit that is the first subunit to accept electrons from NADH. The NDUFVI knockdown enhanced C2C12 myogenesis by decreasing the NAD(+)/NADH ratio and subs...
متن کامل1 Loss of PDGF - B activity increases hepatic vascular 2 permeability and enhances insulin sensitivity 3 4 Running title : PDGF - B deficiency enhances insulin sensitivity
Running title: PDGF-B deficiency enhances insulin sensitivity 5 6 Summer M. Raines, Oliver C. Richards, Lindsay R. Schneider, Kathryn L. Schueler, Mary 7 E. Rabaglia, Angie T. Oler, Donald S. Stapleton, Guillem Genové, John A. Dawson, Christer 8 Betsholtz, and Alan D. Attie 9 10 11 Department of Biochemistry; University of Wisconsin-Madison; Madison, WI 53706 12 Graduate Program in Cellular and...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2005
ISSN: 0021-9258
DOI: 10.1074/jbc.m502163200